Study of the Impact of the Stage of Chronic Renal Failure on Plasma Exposure of Kinase Inhibitors (ITK) in Patients Treated for Metastatic Kidney Cancer
The study of the blood concentration of ITK what are pazopanib and cabozantinib at 1 month and 3 months from the start of treatment will allow to evaluate the impact of renal failure on their efficacy and toxicity in patients with metastatic kidney cancer.
• Patient followed for metastatic clear cell renal cell carcinoma.
• Age ≥18 years old.
• Performance Status (PS) according to Eastern Cooperative Oncology Group (ECOG) = 0, 1 or 2
• Patient treated with a VEGF-R inhibitor: pazopanib or cabozantinib for metastatic kidney cancer.
• If patient doesn't have renal failure -\> group 1, or if patient has chronic renal failure according to the moderate stage Chronic Kidney Disease - Epidemiology (CKD-EPI) formula (Clr \<60 ml / min, stage 3) -\> group 2, or if patient have chronic renal failure according to the CKD-EPI formula of severe or terminal stage (Clr \<30 ml / min, stage 4 and stage 5), with or without dialysis -\> group 3.
• Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests and other study procedures.
• Patient having given informed, written and express consent.
• Affiliation to the French Social Security System.